Introduction to Serial Review: Heme Oxygenase and Carbon Monoxide: Medicinal Chemistry and Biological Effects
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منابع مشابه
Introduction to Serial Review: Heme Oxygenase and Carbon Monoxide: Medicinal Chemistry and Biological Effects
Copyright © 2008 JCBN Heme oxygenase (HO) exists as constitutive (HO-2, HO-3) and inducible isoforms (HO-1), the latter which responds to regulation by multiple stress-stimuli [1]. Several signaling molecules (e.g., mitogen-activated protein kinases), transcriptional regulators (activator protein-1, NF-E2-related factor-2, hypoxia-inducible factor-1, Bach-1), as well as two enhancer regions in ...
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(cGMP). Like NO , CO can also activate guanylate cyclase to cause vasodilation [5] ; however, previous studies have indicated that other mechanisms may contribute to the effects of CO on hepatic tone [6] . In their study [4] , the authors found some potentially novel mechanisms by which HO-1 mediates hepatic tone that appear independent of cGMP and, at least in part, independent of CO . The aut...
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Self-preservation is a fundamental tenet exhibited by all organisms and is perhaps most apparent when the organism is confronted by various threats to survival. This concept also holds true at the most basic cellular level where the cell coordinates a series of responses evolved to ensure the best chance of defense and survival. The ability of cells and tissues to mount an adaptive response to ...
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Heme oxygenase-1 (HO-1, encoded by HMOX1) dampens inflammatory reactions via the catabolism of heme into CO, Fe, and biliverdin. We report that expression of HO-1 dictates the pathologic outcome of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). Induction of EAE in Hmox1(-/- )C57BL/6 mice led to enhanced CNS demyelination, paralysis, and mortality, as compar...
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Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection against oxidative stress in vitro and in vivo. In addition to its physiological role in heme degradation, HO-1 may influence a number of cellular processes, including growth, inflammation, and apoptosis. By virtue of anti-inflammatory effects, HO-1 limits tissue damage in response to proinflammatory stimuli and prevent...
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ژورنال
عنوان ژورنال: Journal of Clinical Biochemistry and Nutrition
سال: 2008
ISSN: 0912-0009,1880-5086
DOI: 10.3164/jcbn.2008025